PTPN11 and female infertility: The last group of genes was those with important role in gynoecium or ovule development, such as SHP2, HEC1, SPT, SRS5, CKRC1, VDD, AGO5, PDIL2-1, SEP2, PI, AP3, EDA14 and EDA17. All of these genes were down-regulated except AGO5, PI and EDA14, which was generally in accorded with female sterility.