The rest of the candidates, C2orf15, DENND1B, MRPL30, POC1B, RP4-655J12.3, TMBIM4, BMP2 K, CSRNP2, NCKAP5L, TOMM5, and BAP1, may be novel genes related to T2DM or obesity. The gene discussed is TMBIM4; the disease is obesity due to melanocortin 4 receptor deficiency.