Our previous study suggested that chronic and acute exercise could both reduce obesity and decrease blood sugar level in type 2 diabetic rats as well as improve the phosphorylation and gene expression related to improved skeletal muscle; AMPKα1/2 and its subunits (AMPKα1, AMPKα2) reduced ACC phosphorylation [23]. Here, PRKAA1 is linked to obesity due to melanocortin 4 receptor deficiency.