DKK1 and liver dysplastic nodule: Furthermore, Li et al. indicated thatWnt/β-catenin pathway-mediated podocyte injury via the activation of transient receptor potential channel 6 (TRPC6) is essential for the proper regulation of podocyte structure and function, whereas inhibition of the Wnt/β-catenin pathway by DKK-1 downregulated HG-induced TRPC6 expression and ameliorated podocyte injury in DN [35].