As far as it concerns the density and distribution of lymphocytes subpopulations in dysplastic HPV-related cervical tissues, the correlation with disease regression versus progression has already been underlined [25]; the authors immunohistochemically characterized T cells' phenotype in cervical biopsies of regressive and progressive intraepithelial neoplasia (CIN), demonstrating that regressive lesions showed a greater distribution of CD4+ T cells both in the stroma and in the epithelium, while progressive and/or high-grade lesions (CIN3) showed a higher CD4/CD8 ratio. Here, CD4 is linked to intraepithelial neoplasia.