The perturbations noted with functional responses of islets to glucose challenge could be a multifactorial effect and can be attributed to a reduced threshold of the β-cells under chronic conditions [58] and islet hypertrophy [59] or can be due to the functional loss of insulin receptor [60], hypertriglyceridemia [61], inflammation [6], hyperleptinemia [62], oxidative stress [63], and IR [29]. Here, INSR is linked to hypertriglyceridemia.