Increased localization of CD11b with a concomitant upregulated expression of downstream inflammatory markers IL-6 and TNFα observed here in the Mutant pancreatic islets unequivocally demonstrates an activated macrophage phenotype in the pancreatic islets/tissue and is probably responsible for the localized pancreatic tissue inflammation among Mutants which gets worsened with the severity of disease (obesity) and with age. Here, ITGAM is linked to obesity due to melanocortin 4 receptor deficiency.