TNF and obesity due to melanocortin 4 receptor deficiency: Increased localization of CD11b with a concomitant upregulated expression of downstream inflammatory markers IL-6 and TNFα observed here in the Mutant pancreatic islets unequivocally demonstrates an activated macrophage phenotype in the pancreatic islets/tissue and is probably responsible for the localized pancreatic tissue inflammation among Mutants which gets worsened with the severity of disease (obesity) and with age.