GRIN2A and melanoma: Overall, patients with non-synonymous GRIN2A mutations had faster progression of melanoma from skin lesions to the involvement of lymph nodes (P = 0.04) or distant organs (P = 0.012), and shorter overall survival (P = 0.013) compared with patients with non-mutated GRIN2A (Table 2; Figures 3 and 4A).