GRIN2A and melanoma: Two patients in this study presented with disseminated melanoma and both were found to carry non-synonymous mutations in GRIN2A. The other two patients with the non-synonymous GRIN2A mutations presented with skin lesions that spread to lymph nodes within 9 and 27 months, compared with a median of 37 (0–140) months for patients with non-mutated GRIN2A (P = 0.041; Table 2).