Mast cells can exert pro-tumorigenic effects by secreting factors like VEGF, angiopoietin-1, CXCL1, and IL-8 that promote tumor angiogenesis, as well as growth factors such as PDGF, NGF, SCF, FGF2, and proteases that facilitate tumor cell growth and metastases (118). This evidence concerns the gene NGF and neoplasm.