Mast cells can exert pro-tumorigenic effects by secreting factors like VEGF, angiopoietin-1, CXCL1, and IL-8 that promote tumor angiogenesis, as well as growth factors such as PDGF, NGF, SCF, FGF2, and proteases that facilitate tumor cell growth and metastases (118). The gene discussed is ANGPT1; the disease is neoplasm.