Haan et al. [27] found that ApoE ε4 carriers had significantly lower CRP levels than noncarriers and that higher CRP levels were associated with a decreased risk of incident all-cause CIND/dementia among ApoE ε4 carriers [OR = 0.60; 95% CI (0.20, 0.91) P = 0.03]. This evidence concerns the gene APOE and dementia.