The etiology of the nonobstructive azoospermia associated hypogonadism in our subject was investigated including chromosomal analysis which showed a normal male 46 XY pattern and testicular biopsy confirmed Sertoli cell only syndrome in line with the elevated serum FSH, normal or high LH, normal or low testosterone, and low inhibin B [1]. This evidence concerns the gene PLOD1 and hypogonadism.