F2 and hepatocellular carcinoma: We have recently published two studies on the prevalence of these THRGFs in liver cirrhosis and hepatocellular carcinoma: MTHFR677TT was highlighted as a significant risk factor for PVT in liver cirrhosis [1], but PAI-1 was not analyzed in the first study; in the second study [2] MTHFR677TT, PAI-1 4G-4G, and Prothrombin 20210A were found to be significant risk factors in hepatocellular carcinoma, mainly in the presence of portal vein thrombosis (PVT).