The most relevant result of the present study was the pivotal role of PAI-1 4G-4G and MTHFR677TT in this series of Caucasian patients with abdominal thrombosis without liver cirrhosis or hepatocellular carcinoma; PAI-1 4G-4G has come out as the lead factor in the total abdominal thrombosis group, with similar prevalence in PVT (30/54) and BCS (17/31), confirming its important role in pathogenesis of portal thrombosis, as found by Balta et al. [8], and confirming itself as a thrombotic risk factor in different target organs, as showed by Tsantes et al. [9]. The gene discussed is SERPINE1; the disease is cirrhosis of liver.