One trial of 160 women with a history of fetal loss after 10 weeks of gestation and the presence of a hypercoagulable state including Factor V Leiden, prothrombin gene mutation, or protein S deficiency randomized women to either low dose aspirin or prophylactic doses of enoxaparin for the duration of pregnancy [51]. This evidence concerns the gene PROS1 and hyperinsulinemic hypoglycemia, familial, 4.