The mean values of low-density lipoprotein cholesterol in the obese subjects were significantly different (P < 0.05) among the three genotypes (GG = 2.40 ± 0.16 mmol/L, GA = 2.20 ± 0.09 mmol/L, and AA = 3.31 ± 0.45 mmol/L) at the PSMA3 locus irrespective of family obesity history. Here, PSMA3 is linked to obesity due to melanocortin 4 receptor deficiency.