Although it is attractive to speculate that PSMA3 is involved in regulation of LDL cholesterol levels and such genetically-regulated changes in LDL levels are consistent with dyslipidemia being a major cofactor in the etiology of obesity, it is still premature to propose LDL differences as the mechanism involved in development of obesity in our case group subjects. Here, PSMA3 is linked to obesity due to melanocortin 4 receptor deficiency.