Along with previous studies that have demonstrated an association between SNPs at the PSMA6 rs1048990 and PSMA6 rs12878391 loci and myocardial infarction and coronary artery disease [29], our results are consistent with the hypothesis that proteasomal gene mutations may play an important role in the development of coronary artery disease. The gene discussed is PSMA6; the disease is coronary artery disorder.