Since, to our knowledge, there have been no previous studies of SNPs and obesity in children analyzing the association of proteasomal gene polymorphisms with lipoprotein levels, the results support further investigation focusing on the nature of the relationship between PSMA3 polymorphisms and LDL-cholesterol levels, both developmentally and clinically. Here, PSMA3 is linked to obesity due to melanocortin 4 receptor deficiency.