As compared to TMME, expression of the same genes by HaCaT cells, which havebeen previously considered to be a conventional two-dimensional cellular modelto study psoriasis, has not met our expectations(Fig. 5A andFig. 6, respectively).For instance, the treatment with TN F and IFNG suppressed mki67expression (Fig. 6A).The different responses of HaCaT and TMME tothis treatment can be explained by the deviation from the physiological optimumof HaCaT cells. This evidence concerns the gene IFNG and psoriasis.