Keratinocyte-specific ILK (K5-Cre) gene knockout inmouse (keratin 5 gene promoter controlled Cre-recombinase) led to thedisturbance of keratinocyte adhesion and BM integrity, blisters formation,keratinocyte ectopic proliferation in the suprabasal layers, abnormalkeratinocyte differentiation, epidermal hyperplasia, defects in HF formation,and alopecia. The gene discussed is KRT5; the disease is hydrops fetalis.