Defects in NADPH supplying enzymes, such as glucose-6-phosphate dehydrogenase (G6PD) deficiency in humans, compromise recycling of glutathione and thioredoxin and so weaken antioxidant capacity and confer susceptibility toward oxidative insult [37]. The gene discussed is G6PD; the disease is hyperinsulinemic hypoglycemia, familial, 4.