EDN1 and Insulin resistance: In ZFs, excessive visceral adiposity, increased macrophage infiltration and the elevated levels of 8-isoprostane, MIP-1α, MCP-1, TNF-α, IL-6, IL-1β, and ET-1 proteins of heart failure, and extracellular-matrix deposition are among the complex molecular processes that characterize the intricate relationship between inflammation, oxidative stress, cardiac fibrosis, and the progressive development of insulin resistance and cardiomyopathy [5, 47–49, 55–57].