Though our studies have not formally established that CD25+ FOXP3+cells exerted suppression, nevertheless, they seem to be associated with the T cell anergy in leprosy as both CD25hi (p<0.03) and CD25low (p<0.004) FOXP3+ cells showed significant increases in the anergic lepromatous as compared to the limited form of tuberculoid leprosy. This evidence concerns the gene FOXP3 and tuberculoid leprosy.