CCNE1 and acute lymphoblastic leukemia: In ALL, alterations in Cyclins D1 -CCND1 [5], [6], D3 -CCND3 [7], E1 -CCNE1 [8] and A1-CCNA1 [9], Cyclin dependent kinases (CDK) 2 &6 -CDK2 & CDK6 [10], [11] [Figure 1], cyclin dependent kinase inhibitors CDKN2A, CDKN2B [12], CDKN1B [13], CDKN1C [14] have been reported.