This is contrasted by studies demonstrating that the G-rich region upstream of the P1 promoter of the c-Myc gene controls ∼90% of its transcriptional regulation and that G4 ligands can stabilize the c-Myc promoter quadruplex and disable c-Myc in childhood medulloblastoma cells in vitro[54], [55], [56]. The gene discussed is MYC; the disease is medulloblastoma.