Our recent studies in methionine and choline deficient (MCD) diet fed mice, which develop hepatic steatosis, inflammation, apoptosis, and fibrosis histologically similar to human NASH [16], [17], demonstrated that PKCδ protein expression and activation are elevated in the liver of mice fed the MCD diet compared to a control diet [18]. The gene discussed is PRKCD; the disease is metabolic dysfunction-associated steatohepatitis.