IL18 and renal fibrosis: In line, IL1-β deficiency did not affect accumulation of myofibroblasts or collagens in kidneys following obstruction-induced renal fibrosis [39], whereas transgenic mice with neutralized IL-18 by IL-18 binding protein exhibited reduced collagen deposition and myofibroblast accumulation during UUO, without altering the concentrations of TGFβ [40].