Since Nordy can inhibit angiogenesis by regulating CXCR4-mediated production of VEGF by glioma cells [32], we attempted to confirm whether the combination of Nordy and the VEGF receptor tyrosine kinase inhibitor could enhance suppression of angiogenesis that was induced by GSCs (Figure 3F). The gene discussed is CXCR4; the disease is central nervous system cancer.