ALOX5 and cancer: Since the verified VEGF receptor tyrosine kinase inhibitors markedly inhibit angiogenesis induced by xenografted U87 GSCs, we next evaluated the effects of Nordy, which is also capable of modulating several hallmarks of cancer including robust proliferation, and resistance to apoptosis by inhibiting the Alox-5 pathway in the process of tumor angiogenesis in vivo[28]–[30].