PAX6 suppresses glioblastoma cell growth, anchorage-independent growth and glioma angiogenesis as well as invasiveness of glioblastoma cell, via inhibition of matrix metalloproteinase-2 (MMP2) expression and vascular endothelial growth factor A (VEGFA) expression [20], [23], [24]. Here, PAX6 is linked to central nervous system cancer.