Since thiaminase should inhibit two key TDEs involved in Krebs cycle metabolism, pyruvate dehydrogenase complex and 2-oxoglutarate dehydrogenase (2-OGDH, aka alpha-ketoglutarate dehydrogenase), we examined respiration (as oxygen consumption rate; OCR) and the rate of extracellular acidification (a measure of lactate production; ECAR) in leukemia and breast cancer cell lines. The gene discussed is OGDH; the disease is breast carcinoma.