This hypothesis is further supported by the observation that the stability of NEFL mRNA is regulated by several RNA binding proteins that have been linked to the pathogenesis of ALS, including mutant superoxide dismutase 1 (mtSOD1), TDP-43 and RGNEF [9], [15], [16], [17]. The gene discussed is ARHGEF28; the disease is amyotrophic lateral sclerosis.