Neuronal cytoplasmic inclusions (NCIs) in motor neurons are a neuropathological hallmark of ALS, including aggregates containing neurofilament (NF) [4] or RNA binding proteins such as TAR DNA binding protein of 43 kDa (TDP-43) [5], [6], fused in sarcoma/translocated in liposarcoma (FUS/TLS) [7], [8] and Rho guanine nucleotide exchange factor (RGNEF) [9]. This evidence concerns the gene ARHGEF28 and amyotrophic lateral sclerosis.