Haramati and colleagues [52] have demonstrated in a murine model of progressive motor neuron disease that neuron-specific miR-9, the most abundant miRNA in murine motor neurons, is selectively down-regulated thus allowing for a selective increase in the high molecular weight NF (NEFH) mRNA relative to either NEFL or NEFM. Using a commercially available array to examine miRNA expression in the frontal cortex of ALS patients, Shioya and colleagues [53] observed an up-regulation of miR-29a, miR-29b and miR-338-39. Here, NFASC is linked to amyotrophic lateral sclerosis.