In fact this association with chromosome 3p loss has recently been strengthened by several publications demonstrating that 4 out of five (VHL, PBRM1, SETD2 and BAP1) of the most frequently mutated genes associated with CCRCC are on chromosome 3p [6]–[10] and that the mutation of either SETD2, BAP1 or PBRM1 associates with poorer prognosis or progression in those patients [6], [20], [21]. The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.