SFRP1 hypermethylation strongly correlated with poorer patient survival in the HumanMethylation27 BeadChip cohort, with 3 of 6 statistically significant probes representing SFRP1. One probe represented a more significant prognostic marker for patient survival than tumor stage, grade or dimension and remaining two probes were statistically significant markers after tumor stage. The gene discussed is SFRP1; the disease is neoplasm.