At this point, the potential roles of dysferlin on RBCs or in RBC maturation are mainly speculative, whether these are specific to the DBA pathology and impaired ribosome biogenesis, or whether the expression of dysferlin allows DBA erythropoiesis to produce circulating RBCs and rescue RBC production in the context of impaired ribosome biogenesis remains to be determined. The gene discussed is DYSF; the disease is Diamond-Blackfan anemia.