TP53 and systemic lupus erythematosus: [40] Furthermore, a decrease in CR1 is also associated with systemic lupus erythematosus, further suggesting a link between DBA and an increased immune response. [41] Interestingly, a link between p53 and MVP has been described in which MVP was upregulated during p53 over-expression in human diploid fibroblasts and p53 was shown to directly bind to the MVP promoter. [42] Therefore, the increased activation of p53 in DBA erythroid progenitors [7] may explain the increase of MVP in DBA RBCs.