Therefore, we developed a calculator for HF stratification that, in addition to classical risk factors, includes N-terminal pro B-type natriuretic peptide (NT-proBNP), a marker of myocardial stretch; high-sensitivity cardiac troponin T (hs-cTnT), a marker of myocyte injury; and high-sensitivity soluble ST2 (ST2), which is reflective of myocardial fibrosis and remodeling. Here, NPPB is linked to Myocardial fibrosis.