BAG1 and cancer: Since physiological functions of BAG-1 have been linked both to cancer and to steroid receptor activity, such as dexamethasone induced apoptosis [49], hormone-dependent tumors, or stress-related phenotypes [50], [51], our study suggests that more research is needed to explore whether HspBP1 may play a particular role in steroid-dependent tumors and, similar to BAG-1, in stress hormone physiology.