CHKA and neoplasm: As an important molecule in the Wnt signaling pathway, Axin participates in formation of the Axin/glycogen synthase kinase 3β (GSK-3β)/adenomatous polyposis coli (APC)/Casein kinase I (CKI) degradation complex, which enhances the degradation of β-catenin and inhibits tumor proliferation, invasion, and metastasis [14]–[15].