By MTT assay in vitro, we observed the inhibition of PI3K/Akt pathway sensitized K562/ADR cells to chemotherapy (Fig. 5B), the similar results were also observed by in vivo chemosensitivity analysis, reduced tumor volumes were detected in mice group bearing K562/ADR tumors with impaired PI3K/Akt signaling (Fig. 5C). The gene discussed is AKT1; the disease is neoplasm.