AFP and hepatitis B virus infection: Univariate analysis identified the following seven variables as risk factors promoting HCC recurrence in patients with hepatitis B: antiviral treatment (p<0.001), smoking status (p = 0.033), smoking pack-years (p<0.001), AFP higher than 20 ng/mL (p = 0.018), tumor size larger than 5 cm (p = 0.005), multiple tumor lesions (p = 0.042), surgical margin less than 1 cm (p = 0.048) and perioperative blood transfusion quantity more than 600 mL (p = 0.004).