B2M and lymphoma: There are also several well-known prognostic clinical and laboratory predictors for newly diagnosed malignant lymphoma, such as International Prognostic Index (IPI), Follicular Lymphoma IPI (FLIPI), and elevated levels of serum thymidine kinase (TK), Beta 2-microglobulin (B2m), lactate dehydrogenase (LD) and C-reactive protein (CRP).