The aforementioned experiments using Fpn1Tek/Tek and Fpn1Alb/Alb;LysM/LysM mice suggest that factors other than liver iron levels regulate the expression of Bmp6. Because Tf-bound iron [23], anemia, Epo, and erythropoietic activity [5], [33]–[34] are all factors that influence Hamp1 expression, we hypothesized that some or all of these factors might be involved in regulating Bmp6 expression in our mouse models. The gene discussed is EPO; the disease is anemia (phenotype).