Besides the identification of tumor-initiating HCC cells, cancer-related molecules and signaling pathways, such as the polycomb group proteins, NANOG, AKT/PKB signal, and Wnt/β-catenin, have been shown to play an important role in maintaining or augmenting of tumor-initiating capability of TICs [4]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.