Interestingly, SNAI1 established by several groups including us to take part in EMT induction by GLI1 was found not to be up-regulated by Cav-1 in vitro in this investigation, whereas Twist, another well-known EMT inducer of HCC, was found up-regulated by Cav-1, which points out that GLI1 could induce HCC cell EMT through both the GLI1-SNAI1 axis and the GLI1-Cav1-Twist cascade. The gene discussed is GLI1; the disease is hepatocellular carcinoma.