The XRCC3 gene is located in human chromosomes 14q32.3 and various polymorphisms in this gene have been identified with susceptibility to cancers such as Thr241Met (C18067T, rs861539), 5-UTR (A4541G rs1799794) and IVERSUS 5–14 (A17893G, rs1799796). The gene discussed is XRCC3; the disease is cancer.