The in vivo anti-tumor efficacy of the anti-Her2 position 1-ADC, anti-Her2 position 2-ADC against the anti-Her2 Cys-ADC in the NCI-N87 gastric cancer (Figure 5A) and HCC-1954 breast cancer (Figure 5B) xenografts grown in male and female SCID mice respectively. Here, ERBB2 is linked to breast carcinoma.