EGFR and gastric cancer: Several limitations in the present study need to be addressed: (1) the sample size may not have been large enough to detect SNPs with a low variant frequency, such as rs4698803 and rs28384375; (2) the polymorphisms that were investigated were selected based on known SNPs and may not give a comprehensive view of the genetic variability of the EGF, TGFA, and EGFR; and (3) detailed information about the GC cases was not collected, including patient survival, whether the tumors were of the intestinal or diffuse type, whether or not there was metastasis, and the effectiveness of drug therapy.