Stepwise multiple linear regression analysis showed that higher BMI (regression coefficient β = 1.59; t = 10.3; P < 0.001) and female gender (regression coefficient β = 6.02; t = 2.41; P = 0.019) have had significant effect on serum leptin levels accounting effect of other covariates such as age, rhinitis, IgE, FEV1 Z-score, and FVC Z-score. The gene discussed is LEP; the disease is rhinitis.