Specific miRNAs miR-155, miR-564, and miR-31 are downregulated in CML and extrapolation of these results suggested that VEGF, mTOR, ErbB, and MAPK are the main signaling pathways related to the miRNAs [158]. This evidence concerns the gene EGFR and chronic myelogenous leukemia, BCR-ABL1 positive.