PRNP and human prion disease: Using a set of PrP-specific monoclonal antibodies two distinct C- and N-terminally ragged PK-resistant PrPres fragments of approximately 8 kDa and 5 kDa which are differently truncated at their C-termini were detected, thus confirming the complexity and the specificity of the molecular PrPres phenotype of these atypical scrapie isolates [199] and its similarities with some human TSE variants such as GSS-P102L and VPSPr (Figures 1 and 2) [200].