More specifically, in the first, the inoculation of brain extracts from a GSSP102L patient with no spongiform change caused almost no clinical disease but induced striking PrP-amyloid deposition in brains of several recipient mice; extracts of those brains failed to transmit neurological disease on further passage but again induced PrP-amyloid plaques in recipient mice [173]. The gene discussed is PRNP; the disease is nervous system disorder.