CYP19A1 and metabolic syndrome: Moreover, TRT in hypogonadal males is able to influence metabolic parameters causing a reduction of fasting plasma glucose, HOMA-IR, triglycerides, waist circumference, and usually augmenting HDL cholesterol [19, 31–34]; also, estrogens, which increase after TRT due to aromatase-mediated conversion [35, 36], have been found to be positively associated with metabolic syndrome [37].