“LEPREL1 expression in human hepatocellular carcinoma and its suppressor role on cell proliferation” by J. Wang et al. found that LEPREL1 was downregulated in hepatocellular carcinoma (HCC) tissues both in mRNA and protein levels, and the down-regulation was not associated with conventional clinical parameters of HCC. This evidence concerns the gene P3H2 and hepatocellular carcinoma.