However, nearly twice as many 4N cells are Igf1r (or Pdgfra) positive versus Igf1r (or Pdgfra) negative, suggesting these Pax3:Foxo1a targets may have a functional role late in the cell cycle, such as the Igf1r-mediated radioresistance seen for other forms of cancer [10]. This evidence concerns the gene FOXO1 and cancer.