TREM1 and Sepsis: The detection of TREM-1 in inflammatory lesions caused by bacterial or fungal agents, but not in psoriasis or immune-mediated vasculitis [9], has further led to the general concept that TREM-1 is primarily involved in microbial diseases, particularly, since elevated levels of the serum soluble form of the shed TREM-1 surface receptor (sTREM-1) also appear to associate with bacterial infections in patients with pneumonia or suspected sepsis [13], [14].