Whereas in the colitis model we have not analysed CD4+ T cell responses in more detail, CD4+ T cells isolated from L. major-infected and CD8+ T cells retrieved from influenza virus-infected Trem1−/− mice, respectively, exhibited an unimpaired capacity for IFNγ production compared to T cells from Trem1+/+ mice. The gene discussed is CD8A; the disease is colitis.