In the majority of instances, the Marfan syndrome is caused by a mutation of the FBN-1 gene, which codifies the fibrillin-1, a large 350 kDa glycoprotein that is sited in the extracellular matrix and is fundamental to maintain the integrity of the vessel wall, promoting the anchorage of smooth muscle cells (SMCs) to the matrix of elastin and collagen [13]. This evidence concerns the gene FBN1 and Marfan syndrome.