In the present study, we reported the significant effect of physical activity on HDL-C levels, which was confirmed to be a risk factor for mortality in hemodialysis patients, independent of age, sex, body mass index, time on hemodialysis, presence of diabetes mellitus, albumin, creatinine, intact PTH, LDL-C, TG, lipid-modifying medications, and the Brinkman index. The gene discussed is ALB; the disease is diabetes mellitus.