Moreover, in peritoneal macrophages, the frequencies of Tim-4+ cells in BD mice were significantly higher than those in Nor and BDN mice (Nor versus BDN versus BD (%): 6.1 ± 2.0 (n = 5) versus 8.6 ± 4.0 (n = 9) versus 26.6 ± 17.0 (n = 5), Nor versus BDN,  P = 0.11, Nor versus BD,  P = 0.02, BDN versus BD,  P = 0.005). This evidence concerns the gene TIMD4 and Behcet disease.